All documents are arranged by topic. Simply click on the title you are interested in learning more about. All PDF documents are available for download.
Please remember, we are not veterinarians. All documents are provided for you to discuss with your veterinarian. All treatment decisions should be made in partnership with a trusted veterinarian.
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*Note: If you are quoting and/or referencing any of our listed documents, please credit the author (if no author is listed, credit CARE).
CARE Interviews with Addison’s Researchers & Others:
- Click here to visit our YouTube channel!
- Be the Advocate Your Addison’s Dog Needs – CARE Interview with Dr. Nancy Kay, DVM, DACVIM, July 16, 2022
- CARE Interview with Canine Addison’s Genetics Researcher, Dr. Steven Friedenberg, September 18, 2021
- CARE Interview with Canine Addison’s Researcher, Dr. Daniel Langlois, co-author of MSU’s Low Dose DOCP study, November 10, 2021
- Canine Addison’s Disease – The Great Pretender – Chester Springs (PA) Library Webinar with Lori Basher, co-founder of CARE
Frequently Requested Documents & Videos:
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- Symptoms of Addison’s Disease in Dogs
- Canine Addison’s Disease – The Basics – Brief Summary
- So Your Dog Was Diagnosed with Typical Addison’s & is on Percorten or Zycortal
- So Your Dog Was Diagnosed with Typical Addison’s & is on Florinef, Fludrocortisone, or Astonin-H
- So Your Dog Was Diagnosed with Atypical Addison’s
- Signs of too much Prednisone, Prednisolone, or other glucocorticoid
- The Importance of Cortisol in Dogs and Cats
- Surgery & Medical Procedures for Dogs with Addison’s Disease
- Reference Ranges & Blood Sample Conditions: Hemolysis & Lipemia
- Percorten or Zycortal Tracker – Use this to keep a chart of your dog’s injection dates and amounts
- Florinef, Fludrocortisone, or Astonin-H Tracker – Use this to keep a chart of your dog’s medication amounts
- Click here to see which states in the US require veterinarians to provide a written prescription for active patients
- How to draw up Percorten or Zycortal
- How to administer a subcutaneous injection for your pet
- Injection tips for giving DOCP injections at home
- This is what you can expect dogs with Addison’s to look like after they recover from crisis and diagnosis – Meet Henry!
Low Dose Percorten or Zycortal (DOCP) Studies:
- MSU Study: Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial
- MSU Press Brief: New Dosage Protocol for Dogs with Addison’s Disease: A Randomized Controlled Clinical Trial
- Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism
- Abstract – Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism
- CARE Interview with Canine Addison’s Researcher, Dr. Daniel Langlois, co-author of MSU’s Low Dose DOCP study, November 10, 2021
CARE Survey Results:
- CARE Survey – Canine Addison’s – Low Dose DOCP (Percorten & Zycortal)
- CARE Survey – Canine Addison’s – Low Dose Pred – Sorted by mg per kg
- CARE Survey – Canine Addison’s – Low Dose Pred – Sorted by weight
- CARE Survey – Canine Addison’s – Percentage by Type of Addison’s
- CARE Survey – Canine Addison’s – Age at Diagnosis
- CARE Survey – Canine Addison’s – Percentage by Gender
- CARE Survey – Canine Addison’s – Numbers by Breed
Addison’s Disease (General):
- Symptoms of Addison’s Disease in Dogs
- Canine Addison’s Disease – The Basics – Brief Summary
- CARE Awareness Document for Sharing
- So Your Dog Was Diagnosed with Typical Addison’s & is on Percorten or Zycortal
- So Your Dog Was Diagnosed with Typical Addison’s & is on Florinef, Fludrocortisone, or Astonin-H
- So Your Dog Was Diagnosed with Atypical Addison’s
- Effect of long-term management of hypoadrenocorticism on the quality of life of affected dogs and their owners – Hupfeld, Dölle, Volk, & Rieder
- Addison’s disease: What’s new with the great pretender?
- MSU Study: Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial
- New Dosage Protocol for Dogs with Addison’s Disease: A Randomized Controlled Clinical Trial
- Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism
- Planning for Surgery & Medical Procedures for Dogs with Addison’s Disease
- Novartis Roundtable Discussion on Addison’s Disease
- Issues in Endocrinology – See Pages 20-26
- Canine Hypoadrenocorticism – David Bruyette, DVM, DACVIM 2013 CVC Conference Presentation
- Lori Basher – Canine Addison’s Resources & Education – Interviewed by Animal Care Trust USA
- Traduit vers le français
- Symptômes de la maladie d’addison chez les chiens
- La maladie d’Addison chez les chiens – Sommaire des points saillants
- Votre chien a été diagnostiqué de la maladie d’addison typique – Percorten ou Zycortal
- Votre chien a été diagnostiqué de la maladie d’addison typique – Florinef
- Votre chien a été diagnostiqué de la maladie addison atypique
- Préparation en vue d’une chirurgie ou de procédures médicales pour les chiens atteints de la maladie d’Addison
- En español
- Hipoadrenocorticismo en Perros – Carlos Melián – Hospital Clínico Veterinario ULPGC
- Enfermedad de Addison Canina – Lo básico – Breve Resumen
- Así que su perro fue diagnosticado con addison primario – Para perros con Percorten o Zycortal
- Así que su perro fue diagnosticado con addison primario – Para perros con Florinef/Fludrocortisona/Astonin-H (pastillas diarias)
- Así que su perro fue diagnosticado con addison atípico
- Síntomas de Exceso de Prednisona
- Cómo planificar para una cirugía o procedimiento en un perro con Addison
- Käännetään suomeksi
- Koirasi on siis saanut diagnoosiksi tyypillinen addisonin tauti – Suunnattu koirille jotka ovat Percorten tai Zycortal lääkityksellä
- Koirasi on siis saanut diagnoosiksi tyypillinen addisonin tauti – Suunnattu koirille jotka ovat Florinef/Fludrokortisoni/Astonin-H lääkityksellä (päivittäinen pilleri)
- Koirasi on siis saanut diagnoosiksi epätyypillinen addisonin tauti
- Prevedeno na hrvatski jezik
- Simptomi Addisoneve Bolesti Kod Pasa
- Oversatt til norsk
- Symptomer på Addison`s Sykdom hos Hunder
- Tegn på For Mye Prednisolon
- Översatt till svenska
- Symtom på Addisons sjukdom hos hund
- Μεταφρασμένο στα Ελληνικά
- Συμπτώματα της Νόσου του Άντισον στους σκύλους
Medications:
-
Percorten-V™ – The Gold Standard in Addison’s Treatment
- So Your Dog Was Diagnosed with Typical Addison’s & is on Percorten or Zycortal
- Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism
- New Dosage Protocol for Dogs with Addison’s Disease: A Randomized Controlled Clinical Trial
- How to draw up Percorten or Zycortal
- How to administer a subcutaneous injection for your pet
- CARE – Low Dose Percorten
- Interview with Dr. Julia Bates – regarding Addison’s Disease and Low Dose Percorten
- Q & A: Prolonged Action of Percorten in a Dog with Addison’s Disease
- Percorten & Zycortal Starting Doses By Weight
- Percorten-V™ Product Insert
- Percorten-V™ Monograph – Canine Hypoadrenocorticism: Diagnosis and Treatment of an Emerging Disease
- Subcutaneous Administration of Percorten
- View this video of one of our Facebook group members administering an injection to Elsa
- The Fascinating Story of Percorten-V™
- Abstract – Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism
- Traduit vers le français
- Votre chien a été diagnostiqué de la maladie d’addison typique –
Percorten ou Zycortal - En español
- Así que su perro fue diagnosticado con addison primario – Para perros con Percorten o Zycortal
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Zycortal® – Zycortal is nearly identical to Percorten-V™, so please also reference the Percorten section above. Percorten has been around much longer & more has been written about it.
- So Your Dog Was Diagnosed with Typical Addison’s & is on Percorten or Zycortal
- Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism
- New Dosage Protocol for Dogs with Addison’s Disease: A Randomized Controlled Clinical Trial
- How to draw up Percorten or Zycortal
- How to administer a subcutaneous injection for your pet
- View this video of one of our Facebook group members administering an injection to Elsa
- A Guide for UK Addison’s dog owners – Florinef to Zycortal 2016 – Updated May 2016
- Percorten & Zycortal Starting Doses By Weight
- Previous Zycortal Survey – Reported Issues
- Previous Zycortal Survey – Reported Issues, Doses, & Electrolytes
- Summary of the European Public Assessment Report (EPAR) for Zycortal
- Zycortal® Package Insert
- Statement from Dechra re: Zycortal April 2016
- Zycortal Freedom of Information Summary – Original New Animal Drug Application
- Zycortal – Annex I – Summary of Product Characteristics
- CVMP Assessment Report for Zycortal
- Zycortal – Summary of Opinion – Initial Authorisation
- The College of Veterinary Medicine – Are you Addison’s Aware? Zycortal
- Zycortal – Zusammenfassung des EPAR für die Öffentlichkeit
- Zycortal – EPAR-samenvatting voor het publiek
- Zycortal – Résumé EPAR à l’intention du public
- Zycortal – Resumen del EPAR para el público
- La Enfermedad de Addison – Zycortal en el tratamiento del hipoadrenocorticismo
- Traduit vers le français
- Votre chien a été diagnostiqué de la maladie d’addison typique –
Percorten ou Zycortal - En español
- Así que su perro fue diagnosticado con addison primario – Para perros con Percorten o Zycortal
-
Florinef/Fludrocortisone/Astonin-H
- So Your Dog Was Diagnosed with Typical Addison’s & is on Florinef, Fludrocortisone, or Astonin-H
- Fludrocortisone Acetate (Florinef)
- Hypoadrenal Gland Disease (shows Florinef dosing at 0.1mg for every 10 pounds or 5 kg)
- Q & A: Florinef Resistance in Dogs with Addison’s Disease
- Traduit vers le français
- Votre chien a été diagnostiqué de la maladie d’addison typique –
Florinef - En español
- Así que su perro fue diagnosticado con addison primario – Para perros con Florinef/Fludrocortisona/Astonin-H (pastillas diarias)
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Glucocorticoids – Prednisone & Others – Dogs on Percorten or Zycortal Need a Small Daily Dose of Prednisone or Another Glucocorticoid
- Signs of too much Prednisone, Prednisolone, or other glucocorticoid
- The Importance of Cortisol in Dogs and Cats
- Prednisone – From US National Library of Medicine
- Why dogs on Percorten need a daily dose of Prednisone or other glucocorticoid
- The Half-Life of Pred
- Controlling Polyuria in Addison’s Dogs Treated with Prednisone
- Corticosteroid Converter & Half-Life Chart
- Corticosteroid Conversion Calculator including Mineralcorticoid Potency
- Corticosteroid Comparison Chart
- Traduit vers le français
- Symptômes d’excès de prednisone
Diagnosis:
-
ACTH Stimulation Test – the only definitive test for diagnosing Addison’s Disease
- Chart of Atypical vs Typical Addison’s Blood Test Results
- Why the ACTH test should not be repeated for a dog who has already been diagnosed with Addison’s Disease
- Urine Cortisol:Creatinine Ratio to Diagnose Hypoadrenocorticism in Dogs – Kylie Grady, DVM, North Carolina State University, Adam J. Birkenheuer, DVM, PhD, DACVIM, North Carolina State University
- What’s the Best Protocol for ACTH Stimulation Testing in Dogs and Cats?
- Testing for Addison’s disease
- Canine Hypoadrenocorticism – Addison’s Disease – from NationWide Specialist Laboratories
- Canine Hypoadrenocorticism – Part I – from The Canadian Veterinary Journal
- Canine Hypoadrenocorticism – Part II – from The Canadian Veterinary Journal
- Confirming the Diagnosis of Addison’s Disease in Dogs on Corticosteroids
- Performing an ACTH Stimulation Test in Dogs Treated with Fludrocortisone (Florinef)
- Effect of glucocorticoid administration on serum aldosterone concentration in clinically normal dogs – From The American Journal of Veterinary Research
- Regarding the effect of Prednisone on ACTH test results – see #4 on Page5 – From Frequently Asked Canine and Feline Adrenal and Thyroid Questions at the
Atlantic Veterinary College Endocrinology Laboratory
Understanding Blood Tests:
- Understanding Your Pet’s Diagnostic Testing – From Idexx
- Lab Tests Online – Sample Report
- Reference Ranges & Blood Sample Conditions: Hemolysis & Lipemia
- What is Hemolysis? – Tech Talk from BD Technical Services Department
- The Art of Hemolysis
- Hemolyis Education Flyer
- Why Is My Dog Or Cat’s Blood Sample Hemolyzed? – Ron Hines, DVM, PhD
- Why Is My Dog Or Cat’s Blood Lipemic Index High? – Ron Hines, DVM, PhD
Genetic Research on Canine Addison’s Disease:
- Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing – Friedenberg SG, Lunn KF, Meurs KM.
- Lymphocyte subsets in the adrenal glands of dogs with primary hypoadrenocorticism – Friedenberg SG, Brown DL, Meurs KM, Law JM.
- Great study about breed representation in Addison’s – “Naturally Occurring Adrenocortical Insufficiency – An Epidemiological Study Based on a Swedish‐Insured Dog Population of 525,028 Dogs” – J.M. Hanson, K. Tengvall, B.N. Bonnett, and A. Hedhammar
- Genetic evaluation of Addison’s disease in the Portuguese Water Dog
- Heritability and complex segregation analysis of hypoadrenocorticism in the standard poodle
- Inheritance of hypoadrenocorticism in Bearded Collies
- Clinical features and heritability of hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers: 25 cases (1994–2006)
- Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison’s disease in Portuguese Water Dogs
- Prevalence and clinical features of hypoadrenocorticism in Great Pyrenees dogs in a referred population: 11 cases
Emergency Preparedness Documents:
These documents were created for dogs with Addison’s disease but they can be used for any pet. This document has a lot of pictures and might take a little time to load.:
Here is the fillable version of the emergency information documents. To use these on mobile devices, you will need an app such as Adobe Fill & Sign:
Here is a fillable version of the emergency information documents for all other pets (who do not have Addison’s). To use these on mobile devices, you will need an app such as Adobe Fill & Sign:
[…] manageable and affordable. CARE is available to help dog owners learn all they need to know. CARE has also published a variety of materials that can be downloaded from their site. One in particular is their Fillable Emergency […]